Reference :
ELSA-CA15-3
Available outside the USA CA 15-3 is a human breast tumor-associated antigen, recognized and assayed by two monoclonal antibodies. The first, 115D8*, was raised against antigens from human milkfat globule membranes and the second, DF3*, against a membrane-enriched fraction of a human breast carcinoma. The CA 15-3 antigen recognized by both of these monoclonal antibodies is a high molecular weight glycoprotein found at elevated levels in the sera of breast cancer patients. High pre-operative levels of CA 15-3 are associated with a poor prognosis and correlate to the tumor volume. In patient treatment follow-up, raised concentrations of CA15-3 may indicate the presence of metastases, though low concentrations do not exclude these. When CA15-3 is raised at the outset of treatment, some authors consider its normalisation as an indicator of therapeutic effectiveness. The use of CA 15-3 assays is therefore indicated at all stages in the evolution of a breast carcinoma, though it must under no circumstances be considered a screening test.
Download :
All the files to download are for illustration purposes only. For more
details do not hesitate to contact us.
|
